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Between 2016 and 2019, Dr. Wintermark and her team were finally able to proceed with the first phase of the clinical study involving 24 babies born at 36 weeks of gestation or more, with moderate to severe neonatal encephalopathy, who had been placed on therapeutic hypothermia and had brain damage despite treatment. Using sildenafil in babies with such sequelae despite therapeutic hypothermia was found "feasible and safe". It was therefore important to know whether this drug could have similar effects on the brains of newborn babies Consider this: If you get 16 mpg right now and you follow the steps outlined in "Altering Your Driving Style" and "Maintain Your Vehicle," you're likely to notice a 15 percent improvement in your fuel economy.

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